Organic lead salts
Apexbio Technology LLC Vardenafil HCl Trihydrate 330808-88-3 10mg
Vardenafil HCl Trihydrate (CAS 330808-88-3) is the trihydrate salt form of vardenafil a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) In enzymatic assays vardenafil demonstrates an IC50 of 0 7 nM for PDE5 exhibiting high selectivity over other phosphodiesterase isoforms with significantly higher IC50 values for PDE1 PDE2 PDE3 PDE4 and PDE6 Vardenafil enhances relaxation of human trabecular smooth muscle in response to sodium nitroprusside acetylcholine and electrical stimulation and increases cGMP concentrations in human corpus cavernosum tissue These properties establish its utility in studies addressing cGMP-mediated smooth muscle relaxation and PDE5-related pharmacology
Apexbio Technology LLC VO-Ohpic trihydrate 476310-60-8 25mg
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Medchemexpress LLC VO-Ohpic (trihydrate) | 476310-60-8 | 98.0% | 25 MG
VO-Ohpic trihydrate is a highly potent inhibitor of PTEN, with an IC50 of 46±10 nM. It significantly inhibits PTEN activity at low nanomolar concentrations. It is described as an encouragingly specific and potent PTEN inhibitor, and the most potent inhibitor (IC50=35 nM) of PTEN lipid phosphatase activity.
- Highly potent PTEN inhibitor
- IC50 of 46±10 nM for PTEN
- Molecular weight: 415.20
- Formula: C12H16N2O11V
- Appearance: Solid, light green to green
- Soluble in DMSO (≥ 50 mg/mL); insoluble in H2O
- Useful for in vitro inhibition studies and in vivo applications in mice
Apexbio Technology LLC Peramivir Trihydrate 1041434-82-5 10mg
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
Medchemexpress LLC Tanuxiciclib trihydrochloride | 1983984-11-7 | ≥98.0% | 588.94 g/mol | C26H28Cl3N5O3 | 5 MG
Tanuxiciclib trihydrochloride is the trihydrochloride salt of tanuxiciclib, a cyclin-dependent kinase (CDK) inhibitor supplied as a research-grade solid for biochemical and cell-based studies of CDK signaling and cell-cycle regulation. The compound is provided with high chemical purity and is intended for laboratory research applications only.
Medchemexpress LLC RNase L-IN-1 trihydrochloride | 98.1% | 542.67 g/mol | C27H35FN6O3S | 10 MG
RNase L-IN-1 trihydrochloride is the trihydrochloride salt form of a small-molecule inhibitor of RNase L, supplied for research use to study RNase L-mediated RNA degradation, antiviral responses, and inflammation. The compound is provided as a solid salt suitable for biochemical and cellular assays.
- Inhibits RNase L activity for mechanistic and antiviral research.
- Trihydrochloride salt form improves solubility and handling.
- High purity (~98.1%) suitable for research applications.
- Yellow to brown solid appearance, powder form for storage.
- Molecular formula C27H35FN6O3S; molecular weight 542.67 g/mol.
- Store powder at -20°C for long-term stability; follow supplier guidelines.
Selleck Chemical LLC Peramivir Trihydrate S2716-5mg
Peramivir Trihydrate (BCX-1812 RWJ-270201 S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent specific influenza viral neuraminidase inhibitor with an IC50 of median 0 09 nM
Selleck Chemical LLC Alendronate sodium trihydrate S1624-25mg
Alendronate sodium trihydrate (G-704650 MK-217) a nitrogen-containing bisphosphonate is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis
Selleck Chemical LLC Scopolamine HBr trihydrate
Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55 3 nM
Apexbio Technology LLC VO-Ohpic trihydrate 476310-60-8 10mg
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Apexbio Technology LLC Peramivir Trihydrate 1041434-82-5 50mg
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination